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《医学前沿(英文)》 页码 907-923 doi: 10.1007/s11684-023-1009-7
Alternative splicing of inner-ear-expressed genes
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 250-257 doi: 10.1007/s11684-016-0454-y
Alternative splicing plays a fundamental role in the development and physiological function of the inner ear. Inner-ear-specific gene splicing is necessary to establish the identity and maintain the function of the inner ear. For example, exon 68 of Cadherin 23 (Cdh23) gene is subject to inner-ear-specific alternative splicing, and as a result, Cdh23(+68) is only expressed in inner ear hair cells. Alternative splicing along the tonotopic axis of the cochlea contributes to frequency tuning, particularly in lower vertebrates, such as chickens and turtles. Differential splicing of Kcnma1, which encodes for the α subunit of the Ca2+-activated K+ channel (BK channel), has been suggested to affect the channel gating properties and is important for frequency tuning. Consequently, deficits in alternative splicing have been shown to cause hearing loss, as we can observe in Bronx Waltzer (bv) mice and Sfswap mutant mice. Despite the advances in this field, the regulation of alternative splicing in the inner ear remains elusive. Further investigation is also needed to clarify the mechanism of hearing loss caused by alternative splicing deficits.
Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang
《医学前沿(英文)》 2019年 第13卷 第3期 页码 330-343 doi: 10.1007/s11684-017-0557-0
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
《医学前沿(英文)》 2023年 第17卷 第2期 页码 317-329 doi: 10.1007/s11684-022-0931-4
关键词: lncR-GAS5 miR-193-5p splicing factor SRSF10 autophagy atherogenesis
Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott
《化学科学与工程前沿(英文)》 2016年 第10卷 第2期 页码 186-195 doi: 10.1007/s11705-015-1540-4
关键词: RNA splicing gene expression breast cancer DNA damage CHK1
Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient
《医学前沿(英文)》 2022年 第16卷 第1期 页码 150-155 doi: 10.1007/s11684-021-0846-5
李十中
《中国工程科学》 2011年 第13卷 第2期 页码 50-56
文章分析了用生物燃料替代石油以实现控制全球气候变化、减少石油消耗和环境污染、创造就业机会,实现社会经济的可持续发展的重要性;介绍了国内外生物燃料产业发展历程和趋势,以及在汽车燃料和航空燃料领域的应用现状,提出了我国当前发展生物燃料的战略和对策。
Bing WANG, Qingbin CUI, Shuibo ZHANG
《工程管理前沿(英文)》 2019年 第6卷 第2期 页码 239-248 doi: 10.1007/s42524-019-0018-3
关键词: infrastructure development contract design contract reliability guarantee provision contract engineering
A naive optimization method for multi-line systems with alternative machines
Weichang KONG, Fei QIAO, Qidi WU
《机械工程前沿(英文)》 2019年 第14卷 第4期 页码 377-392 doi: 10.1007/s11465-019-0544-z
关键词: multi-line systems alternative machines feedback control closed-loop optimization
《农业科学与工程前沿(英文)》 2022年 第9卷 第2期 页码 284-294 doi: 10.15302/J-FASE-2021435
Bioenergy, currently the largest renewable energy source in the EU (64% of the total renewable energy consumption), has sparked great interest to meet the 32% renewable resources for the 2030 bioeconomy goal. The design of innovative cropping systems informed by bioeconomy imperatives requires the evaluate of the effects of introducing crops for bioenergy into conventional crop rotations. This study aimed to assess the impacts of changes in conventional cropping systems in mixed dairy cattle farms redesigned to introduce bioenergy crops either by increasing the biomass production through an increase of cover crops, while keeping main feed/food crops, or by substituting food crops with an increase of the crop rotation length. The assessment is based on the comparison between conventional and innovative systems oriented to feed and biogas production, with and without tillage, to evaluate their agri-environmental performances (biomass production, nitrogen fertilization autonomy, greenhouse gas emissions and biogas production). The result showed higher values in the biogas cropping system than in the conventional and feed ones for all indicators, biomass productivity (27% and 20% higher, respectively), nitrogen fertilization autonomy (26% and 73% higher, respectively), methanogenic potential (77% and 41% higher, respectively) and greenhouse gas emissions (15% and 3% higher, respectively). There were no negative impacts of no-till compared to the tillage practice, for all tested variables. The biogas cropping system showed a better potential in terms of agri-environmental performance, although its greenhouse gas emissions were higher. Consequently, it would be appropriate to undertake a multicriteria assessment integrating agri-environmental, economic and social performances.
Alternative energy development strategies for China towards 2030
Linwei MA , Zheng LI , Feng FU , Weidou NI , Xiliang ZHANG ,
《能源前沿(英文)》 2009年 第3卷 第1期 页码 2-10 doi: 10.1007/s11708-009-0014-0
关键词: alternative energy China energy technology pathway six-dimensional evaluation
Hani BENGUESMIA, Nassima M’ZIOU, Ahmed BOUBAKEUR
《能源前沿(英文)》 2021年 第15卷 第1期 页码 213-221 doi: 10.1007/s11708-017-0479-1
关键词: 1512L insulator circular model artificial pollution flashover leakage current discontinuous pollution high voltage
Dimethyl ether as alternative fuel for CI engine and vehicle
Zhen HUANG , Xinqi QIAO , Wugao ZHANG , Junhua WU , Junjun ZHANG ,
《能源前沿(英文)》 2009年 第3卷 第1期 页码 99-108 doi: 10.1007/s11708-009-0013-1
关键词: dimethyl ether (DME) fuel injection combustion process emission control CI engine vehicle
WU Rui, LI Guangyi, ZHANG Zongyi, REN Yulong, HAN Weijian
《环境科学与工程前沿(英文)》 2007年 第1卷 第3期 页码 292-298 doi: 10.1007/s11783-007-0049-6
Sergio A. MARTÍNEZ-GALVÁN, Miguel P. ROMO
《结构与土木工程前沿(英文)》 2018年 第12卷 第1期 页码 67-80 doi: 10.1007/s11709-017-0399-5
关键词: deep foundations bearing capacity resistant moment structural cell 3D numerical modeling
标题 作者 时间 类型 操作
High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas
期刊论文
Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers
Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang
期刊论文
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
期刊论文
Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive splicing
Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott
期刊论文
Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient
期刊论文
Evaluation of the contract reliability for alternative infrastructure project delivery: a contract engineering
Bing WANG, Qingbin CUI, Shuibo ZHANG
期刊论文
A naive optimization method for multi-line systems with alternative machines
Weichang KONG, Fei QIAO, Qidi WU
期刊论文
AGRI-ENVIRONMENTAL ASSESSMENT OF CONVENTIONAL AND ALTERNATIVE BIOENERGY CROPPING SYSTEMS PROMOTING BIOMASS
期刊论文
Alternative energy development strategies for China towards 2030
Linwei MA , Zheng LI , Feng FU , Weidou NI , Xiliang ZHANG ,
期刊论文
Experimental study of pollution effect on the behavior of high voltage insulators under alternative current
Hani BENGUESMIA, Nassima M’ZIOU, Ahmed BOUBAKEUR
期刊论文
Dimethyl ether as alternative fuel for CI engine and vehicle
Zhen HUANG , Xinqi QIAO , Wugao ZHANG , Junhua WU , Junjun ZHANG ,
期刊论文
Life cycle analysis and choice of natural gas-based automotive alternative fuels in Chongqing Municipality
WU Rui, LI Guangyi, ZHANG Zongyi, REN Yulong, HAN Weijian
期刊论文